RecruitingNot ApplicableNCT06801639

Advancing Alzheimer's Care: Home-based tDCS for Affective Symptoms

Advancing Alzheimer's Care: Home-based tDCS (Transcranial Direct Current Stimulator) for Affective Symptoms

Sponsor

The University of Texas Health Science Center at San Antonio

Enrollment

24 participants

Start Date

Jul 15, 2025

Study Type

INTERVENTIONAL

Conditions

Alzheimer Disease

Summary

Participants will be asked to participate in this research study of a device that creates transcranial direct current stimulation (tDCS). The researchers hope to learn if 30 minute sessions of transcranial direct current stimulation (tDCS) improve such a mood or feelings in people with Alzheimer's Disease. This study involves the use of an investigational device called a tDC stimulator. "Investigational" means that the device has not yet been approved by the U.S. Food \& Drug Administration (FDA) for treating Alzheimer's Disease. This study will help find out what effects, good and/or bad, this has. The safety of this device in humans has been tested in prior research studies; however, some side effects may not yet be known.

Eligibility

Min Age: 60 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a home-based brain stimulation device called tDCS (which delivers very mild electrical currents through pads placed on the head) can reduce anxiety, depression, and behavioral symptoms in people with Alzheimer's disease. **You may be eligible if...** - You are 60 or older - You have a diagnosis of Alzheimer's disease (possible or probable) or mild cognitive impairment with biological evidence of Alzheimer's (such as positive amyloid or tau tests) - You have a caregiver who can assist with the treatment sessions at home - You have symptoms like anxiety, agitation, or mood changes related to Alzheimer's **You may NOT be eligible if...** - You have a metal implant in your head (such as a cochlear implant or deep brain stimulator) - You have severe epilepsy or uncontrolled seizures - You are in very advanced stages of dementia - You are unable to tolerate the device Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICETranscranial direct current stimulation (tDCS)

The active-tDCS treatment will consist of a constant 2mA current applied during daily 30-minute sessions with a 30 second ramp up and ramp down at the start and end of the stimulation. The anode electrode will be placed over the left dorsolateral prefrontal cortex (DLPFC) and the cathode electrode over the right DLPFC.

DEVICESham tDCS

Sham-tDCS treatment will consist of the same montage as the active TDCS with the built-in function of the device that has been shown to be indistinguishable from the active treatment in previous trials described in the literature.

Locations(1)

University of Texas Health Science Center at San Antonio

San Antonio, Texas, United States

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NCT06801639

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