RTMS for CHR Based on Personalized Targets Using Magnetoencephalography
RTMS for Clinical High-risk Syndrome of Psychosis Based on Personalized Targets Using Magnetoencephalography
Shanghai Mental Health Center
26 participants
Feb 7, 2025
INTERVENTIONAL
Conditions
Summary
This study is an before-after study in the same subject, which enrolled 26 individuals with high-risk psychiatric syndrome (CHR). The target of subjects intervention relies on the results of magnetoencephalography localization. The medication and dosage remain unchanged during the intervention period or not yet taking antipsychotic medication. The investigators assume that the intervention targets for each CHR subject are individualized.
Eligibility
Inclusion Criteria4
- Clinical diagnosis of Clinical High-Risk Syndrome for Psychosis
- Must be able to right-handed
- Primary school education or above
- Understand and sign a written informed consent form (jointly signed by the guardian and the participant if under 18 years old)
Exclusion Criteria4
- Major physical illnesses (organic lesions such as sensory and motor disorders, neurological disorders, and traumatic brain injury)
- Taboo symptoms for rTMS treatment (such as intracranial metal implants)
- Metal (including orthodontic treatment, dental implants) and tattoos inside the body
- Claustrophobia
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Interventions
RTMS using pseudo stimulus intervention in weeks 1-2, for a total of 10 days. After resting for 2 weeks, enter the 3-4 weeks of real stimulation, with 5 days of intervention per week for a total of 10 days. Application of rTMS for 1Hz low-frequency intervention, with intervention parameters of 1400 sessions, 100% exercise threshold, and a total of 23 minutes per session. After each target intervention, rest for half an hour to one hour.
Locations(1)
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NCT06802952