RecruitingNot ApplicableNCT06804538

Interest of Sperm Insemination at 42 Hours Post hCG Compared to 36h in Intrauterine Insemination

Interest of Sperm Insemination at 42 Hours Post hCG Compared to 36h in Intrauterine Insemination : a Randomized Controlled Trial. SYNcIU

Sponsor

University Hospital, Toulouse

Enrollment

692 participants

Start Date

Sep 9, 2025

Study Type

INTERVENTIONAL

Conditions

Infertility Intrauterine Insemination (IUI)

Summary

Intrauterine insemination (IUI) is a common therapeutic option to treate infertility. Typically performed 36 hours post-hCG injection to trigger ovulation. However, research suggests delaying IUI to 42 hours post-hCG may improve egg quality and sperm synchronization for fertilization, leading to higher pregnancy rates. A proposed superiority study aims to compare IUI timing at 36 hours versus 42 hours post-hCG injection to evaluate its impact on live birth rates. The primary objective is to assess the effectiveness (live birth rates) of IUI at two different post-hCG timing intervals (42-43 hours vs 36-37 hours).

Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 43 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a procedure called Insemination between 36 and 37 hours post hCG and a procedure called Insemination between 42 and 43 hours post hCG for people with infertility and intrauterine insemination (iui). The study is currently recruiting participants at 4 locations. People eligible for this study include women aged 18 Years to 43 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREInsemination between 42 and 43 hours post hCG

Patients will be stimulated by gonadotropins, ovulation will be blocked by a GnRH antagonist then triggered by hCG allowing IU to occur between 42 and 43 hours post hCG

PROCEDUREInsemination between 36 and 37 hours post hCG

Patients will be stimulated with gonadotropin and GnRH antagonist whose ovulation will be triggered and for which intrauterine insemination will be carried out between 36 and 37 hours post hCG