RecruitingPhase 1NCT06805825

A Study of the c-Kit Specific Antibody-Drug Conjugate NN3201 for Advanced and/or Metastatic Solid Tumors Known to Express c-Kit

A Phase 1 Dose Escalation and Expansion Study of the c-Kit Specific Antibody-Drug Conjugate NN3201 in Subjects With Advanced and/or Metastatic Solid Tumors Known to Express c-Kit


Sponsor

Novelty Nobility, Inc.

Enrollment

67 participants

Start Date

Feb 3, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This open-label clinical trial will evaluate the safety and tolerability of NN3201 in subjects with advanced and/or metastatic solid tumors known to express c-Kit.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new antibody-drug conjugate called NN3201, which targets a protein called c-Kit found on certain cancer cells, in people with specific types of advanced cancers that have not responded to standard treatments. **You may be eligible if...** - You are 18 or older - You have an advanced or inoperable solid tumor such as gastrointestinal stromal tumor (GIST), small cell lung cancer, adenoid cystic carcinoma, uveal melanoma, neuroendocrine tumor, or a specific type of kidney cancer - Your cancer has progressed or is no longer responding to standard treatments, including imatinib for GIST - Your heart, liver, kidney, and bone marrow function are adequate - You have a life expectancy of at least 3 months - You are generally in good health (ECOG performance status 0 or 1) **You may NOT be eligible if...** - Your prior cancer treatment has not been washed out long enough before starting this study - You are pregnant or of childbearing potential without using effective contraception Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGNN3201

A c-Kit targeting fully human monoclonal antibody-drug conjugate with MMAE administered intravenously.


Locations(5)

University of Michigan Hospitals

Ann Arbor, Michigan, United States

Case Comprehensive Cancer Center

Cleveland, Ohio, United States

Oregon Health & Science University

Portland, Oregon, United States

The University of Texas MD Anderson Cancer Center

Houston, Texas, United States

NEXT Virginia

Fairfax, Virginia, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

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NCT06805825


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