Complete Closure After Endoscopic Mucosal Resection of Large Non-Pedunculated Colorectal Polyps

This study is testing whether fully closing the wound site after endoscopic mucosal resection (EMR) — a procedure to remove large polyps from the colon without surgery — reduces the risk of complications like bleeding compared to partial or no closure. **You may be eligible if...** - You are 18 or older - You are scheduled for EMR to remove a large flat polyp or lesion (at least 20 mm) from the colon or rectum - You have provided written informed consent **You may NOT be eligible if...** - You have inflammatory bowel disease (Crohn's or ulcerative colitis) - Your colonoscopy is being done urgently (non-elective) - You are in poor general health (ASA classification above 3) - You have a blood clotting problem or low platelets that cannot be corrected - Your polyp is pedunculated (on a stalk) rather than flat - Your polyp shows signs of deep invasion into the bowel wall - Your polyp involves the appendix opening or extends into the small intestine - You are pregnant Talk to your doctor to see if this trial is right for you.