Stories to Prevent (StoP) HPV Cancers
Stories to Prevent (StoP) HPV Cancers: A Communication Intervention to Increase HPV Vaccination Among Diverse Populations.
Milton S. Hershey Medical Center
200 participants
Nov 18, 2025
INTERVENTIONAL
Conditions
Summary
This randomized controlled trial (RCT) evaluates the association of a narrative communication intervention on human papillomavirus (HPV) vaccination rates among 9- to 12-year-olds. The intervention is a brief video from local cancer survivors narrating their stories with an HPV-related cancer diagnosis and recommending the HPV vaccine for cancer prevention. RCT participants will be the parents (n=200) of children ages 9-12 who have not initiated HPV vaccination. Participants will be randomized (1:1) to our intervention or control (placebo video) one week before their child's next primary care visit. Our primary outcome is HPV vaccine initiation (first dose of the HPV vaccine series) among children ages 9-12 at the time of the wellness visit. The study also explores the effect of narratives on theory-based mediators of HPV vaccination, including parents' cognitive (e.g., risk perception) and emotional reactions (e.g., hope, anticipated regret).
Eligibility
Inclusion Criteria4
- Parent/guardian of a 9-12 year old receiving primary care at a Penn State Health clinic
- Their child has not previously received or initiated the HPV vaccine
- Is able to read and understand spoken English or Spanish
- Has a valid email address and access to a mobile phone, table, desktop or laptop computer to engage in the intervention
Exclusion Criteria3
- Parent of guardian is less than 18 years of age
- Unable to read and understand spoken English or Spanish
- Does not have access to a mobile phone, table, desktop or laptop computer
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Interventions
The narrative video intervention has three parts: (1) Cancer experience - the cancer survivor narrates his/her experience with an HPV-related cancer, including diagnosis, treatment, and how cancer affected their personal life or family; (2) Vaccine recommendation - the cancer survivor provides brief information about the safety and effectiveness of the HPV vaccine and recommend that parents get the HPV vaccine for their child to prevent cancers; and (3) Closing message - The sentence "HPV vaccine is cancer prevention. Talk to your child's healthcare provider about getting the HPV vaccine during the next clinic visit" will appear on the screen.
A publicly available video about healthy eating tips for families with children.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06808776