A Phase II Single-Arm Clinical Study to Explore the Efficacy and Safety of Hyperbaric Oxygen in the Neoadjuvant Treatment of Breast Cancer Patients

This study is exploring whether hyperbaric oxygen therapy — breathing pure oxygen in a pressurized chamber — can improve outcomes when added to standard neoadjuvant (pre-surgery) chemotherapy for breast cancer. **You may be eligible if...** - You are a woman between 18 and 60 years old - You have been newly diagnosed with invasive breast cancer (not inflammatory or eczema-type) - Your cancer is locally advanced (AJCC stage III, excluding T3N1M0) or operable but not suited for breast-conserving surgery - You are already recommended for neoadjuvant chemotherapy before surgery **You may NOT be eligible if...** - You have inflammatory breast cancer or eczema-like (Paget's) breast cancer - You are not a candidate for neoadjuvant chemotherapy - You have conditions that make hyperbaric oxygen unsafe (such as certain lung or ear conditions) - You are pregnant Talk to your doctor to see if this trial is right for you.