RecruitingPhase 2NCT06815471
CRF2 Agonist for the Treatment of Worsening Heart Failure
Corticotrophin Releasing Factor 2 for the Treatment of Worsening Heart Failure (WHF) - The CRAFT-WHF Study
Sponsor
Corteria Pharmaceuticals
Enrollment
300 participants
Start Date
Aug 7, 2025
Study Type
INTERVENTIONAL
Conditions
Summary
This study assesses the effects of the investigational drug COR-1167 in subjects hospitalised due to worsening of heart failure (HF)
Eligibility
Min Age: 18 YearsMax Age: 85 Years
Inclusion Criteria7
- Signed written informed consent
- Heart failure hospitalization (HFH) during previous 12 months
- Prescribed an oral loop diuretic for at least 1 month preceding the index event
- NT-proBNP ≥1,000 pg/mL or BNP ≥250 pg/mL
- Requires treatment with i.v. diuretics for volume overload
- At least 1 risk factor for diuretic resistance
- Admitted to the hospital not more than 48 hours prior to randomization
Exclusion Criteria15
- Index event primarily triggered by an acute event (e.g. AMI, PE, arrhythmia)
- Requirement for i.v. inotropic therapy or i.v. vasodilators, mechanical ventilation, high-flow oxygen therapy, or NIV
- Requirement for, or planned use of LVADs, IABP, or any type of MCS
- History of solid organ transplant or active on a transplant list
- SBP \<100 mmHg
- eGFR \< 20 mL/min/1.73 m2
- CABG, PCI, implantation of CRT, heart valve procedure or any cardiac surgery within 1 month prior to screening or planned during the study
- Severe stenotic cardiac valvular disease
- Severe chronic pulmonary disease requiring chronic steroid therapy or chronic oxygen therapy (\> 2 L/min)
- Uncorrected severe hyperthyroidism or hypothyroidism
- Severe restrictive, obstructive, or infiltrative cardiomyopathy
- Body weight \< 70 kg
- Use of any investigational drug(s) within 5 half-lives of screening
- At high risk of death (defined as life expectancy ≤1 year) from causes other than heart failure or any disease that, in the opinion of the Investigator, will preclude their safe participation in this study, and will make implementation of the protocol or interpretation of the study results difficult
- Presence of any other conditions (e.g. geographic, social) actual or anticipated, that the Investigator feels would restrict or limit the subject's participation or compliance with all study procedures Subject is the Investigator or any Subinvestigator, research assistant, pharmacist, study coordinator, other staff or relative thereof directly involved in the conduct of the study
Interventions
DRUGCOR-1167
28-day treatment
DRUGPlacebo
28-day treatment
Locations(43)
View Full Details on ClinicalTrials.gov
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NCT06815471