RecruitingPhase 1NCT06820268

A Study of XS-04 in Patients with Relapsed or Refractory Hematologic Malignancies

A Phase I Trial to Evaluate the Tolerability, Pharmacokinetics and Preliminary Efficacy of XS-04 in Patients with Hematologic Malignancies


Sponsor

NovaOnco Therapeutics Co., Ltd.

Enrollment

168 participants

Start Date

Jan 14, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

Evaluation of the safety, tolerability, pharmacokinetics, and preliminary efficacy of XS-04 in patients with relapsed or refractory hematologic malignancies


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This early-phase study tests an experimental drug called XS-04 in people with relapsed or treatment-resistant B-cell blood cancers (such as B-cell lymphoma), including diffuse large B-cell lymphoma (DLBCL), after standard treatments have stopped working. **You may be eligible if...** - You are between 18 and 75 years old - You have a B-cell blood cancer confirmed by biopsy - Your cancer has returned or stopped responding to existing treatments and there are no other suitable options - You are willing to sign consent and comply with the study **You may NOT be eligible if...** - You have serious organ dysfunction (heart, liver, kidneys) - You have active or uncontrolled brain involvement from your cancer - You are pregnant or breastfeeding - You have active serious infections Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGXS-04 tablet

Each treatment cycle is 28 days, with continuous oral administration, twice daily.


Locations(4)

Beijing Cancer Hospital

Beijing, China

Sun Yat-sen University Cancer Center

Guangdong, China

Affiliated Hospital of Hebei University

Hebei, China

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Hubei, China

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NCT06820268


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