RecruitingPhase 1NCT06821685

Autologous Decidual-like Natural Killer Cells Therapy for Infertility or Adverse Pregnancy History

Clinical Study of Autologous Decidual-like Natural Killer Cells Therapy for Infertility or Adverse Pregnancy History Caused by Abnormal Uterine Natural Killer Cells


Sponsor

The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School

Enrollment

14 participants

Start Date

Feb 13, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The aim of this study is preliminary exploration of the effectiveness and duration of autologous decidual-like NK cells therapy in improving uterine NK cells dysfunction.


Eligibility

Sex: FEMALEMin Age: 22 YearsMax Age: 40 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether infusing a woman's own specially grown immune cells (called decidual-like NK cells) into the uterus can improve outcomes for women with unexplained infertility, repeated IVF failure, recurrent miscarriages, or pregnancy complications related to abnormal uterine immune function. **You may be eligible if...** - You have abnormal uterine natural killer (NK) cell function - You have experienced at least 2 unexplained miscarriages, repeated IVF failure, unexplained infertility, or early severe pregnancy hypertension or fetal growth restriction - You have a desire to become pregnant - Your ovarian function is normal, or you have frozen embryos available - Your uterine lining is at least 7mm thick - Your BMI is between 18 and 30 **You may NOT be eligible if...** - You are currently using progesterone or other hormones that would interfere with the treatment - You have a uterine abnormality or active infection - You have a serious immune or blood condition Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

BIOLOGICALautologous decidual-like NK cells

intrauterine infusion


Locations(1)

The Affiliated Drum Tower Hospital of Nanjing University

Nanjing, Jiangsu, China

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT06821685


Related Trials