RecruitingNot ApplicableNCT06823440

Prevention of CIPN Using Compressive Therapy

Prevention of Chemotherapy-induced Polyneuropathy (CIPN) Using Compressive Therapy

Sponsor

Martina Lojova

Enrollment

100 participants

Start Date

Feb 1, 2025

Study Type

INTERVENTIONAL

Conditions

CIPN in Adjuvant Breast Cancer Patients

Summary

Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of treatment with taxanes and platinum-based drugs, significantly impacting the quality of life of oncology patients. Symptoms such as reduced sensitivity and pain may persist even after treatment ends. Research has shown that compression therapy using gloves and stockings effectively reduces the incidence of CIPN, improves patient adherence to treatment, and has no severe side effects. A study at the Chemotherapy Unit of the Comprehensive Oncology Care Clinic, Masaryk Memorial Cancer Institute, will investigate the efficacy of this therapy. Tight-fitting gloves and compression stockings will be used to limit the flow of cytotoxic agents to peripheral areas. Effectiveness will be assessed through quality-of-life questionnaires, hand strength and coordination tests, and laboratory analyses to identify predictive markers of neuropathy. The study aims to enhance CIPN prevention and integrate this method into clinical practice.

Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether wearing compression gloves and socks during chemotherapy can help prevent nerve damage in the hands and feet — a common side effect called chemotherapy-induced peripheral neuropathy (CIPN) — in people being treated for cancer. **You may be eligible if...** - You are 18 or older - You are starting a chemotherapy regimen known to cause nerve damage (such as taxanes or platinum-based drugs) - You do not currently have nerve symptoms in your hands or feet - You are able to wear compression garments during infusions **You may NOT be eligible if...** - You already have nerve damage or neuropathy in your hands or feet - You have poor blood circulation or peripheral artery disease - You have previously received nerve-damaging chemotherapy - You have diabetes with existing neuropathy - You are unable to tolerate compression garments Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICECompression using surgical gloves and compression knee socks

Compression therapy will be applied using surgical gloves and compression knee socks. The compression itself will take place on the principle of compressing the limbs, which will narrow the blood vessels and thereby limit the flow of cytostatics to the peripheral parts of the body. This is believed to reduce damage to nerve fibers. Special knee socks with compression of 20-30 mm Hg and latex/nitrile surgical gloves will be used for pressure therapy. The size of the compression aids will be determined by the nursing staff (gloves will be a tight-fitting size; they will not cause discomfort). The patients will wear the compression aids for a specific amount of time before administering paclitaxel, throughout paclitaxel infusion, and after the infusion.

Locations(1)

Masaryk Memorial Cancer Institute

Brno, Czechia

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NCT06823440