RecruitingPhase 4NCT06825013

Bronchodilators and Lung Mechanics During Exercise in COPD

Bronchodilators and Dynamic Lung Mechanics During Exercise in COPD: Protocol for a Randomised, Placebo-controlled Crossover Trial


Sponsor

Dr. J. Alberto Neder

Enrollment

25 participants

Start Date

Nov 10, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

Bronchodilators are medications that open the bronchi to help patients with COPD to breathe better. It is still not known exactly how this effect improves shortness of breath in people with COPD. The goal of this clinical trial is to determine whether bronchodilators lower resistance in the smallest airways in the lungs, and whether this will improve the feeling of breathlessness in these patients. The main questions the investigators attempt to answer are: * In patients with COPD, does treatment with a short-acting bronchodilator improve small airway resistance during exercise? * In patients with COPD, does acute treatment with short-acting bronchodilator improve breathlessness and exercise endurance? The investigators will compare short-acting bronchodilators to placebo (a substance that contains no drug) to see if the bronchodilator medications improve small airway resistance and breathlessness during exercise. Participants will: * Visit the research laboratory 3 visits to complete tests of lung function and exercise * Complete 2 identical visits (Visit 2 and 3), one in which the participant receives bronchodilator and one in which the participant receives placebo.


Eligibility

Min Age: 40 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating how bronchodilators — medications that open up the airways — affect lung mechanics and breathlessness during exercise in people with COPD (chronic obstructive pulmonary disease), a long-term lung condition. **You may be eligible if...** - You are 40 or older - You have been diagnosed with COPD - You are a current or former smoker - You are stable (not experiencing a flare-up of symptoms) - You are able to complete an exercise test on a stationary bike **You may NOT be eligible if...** - You have had a COPD flare-up or respiratory infection in the past 4 weeks - You have significant heart disease that makes exercise testing unsafe - You have asthma as a primary diagnosis - You are on supplemental oxygen at rest - You are unable to exercise due to joint or muscle problems Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGBronchodilators inhalation

Salbutamol sulphate (2.5 mg) + ipratropium bromide (0.5 mg)

DRUGPlacebo

Nebulized saline


Locations(1)

Respiratory Investigation Unit, Kingston Health Sciences Center

Kingston, Ontario, Canada

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NCT06825013


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