RecruitingNCT06826287

7T Anatomo-functional Characterization of Structures in the Action Observation Network

More Than Cerebral Cortex: 7T Anatomo-functional Characterization of Cortical, Subcortical, and Cerebellar Structures Involved in THE Network of Action Observation


Sponsor

IRCCS Fondazione Stella Maris

Enrollment

40 participants

Start Date

Dec 2, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

The goal of this study is to explore the anatomical-functional characteristics of the AON circuit (with particular interest for subcortical areas and the cerebellum), and the cortico-subcortical connectivity of the nodes of the AON circuit, using an ultra-high field (7T), high spatial resolution Magnetic Resonance Imaging protocol. The main questions it aims to answer are: * Can we demonstrate the involvement of subcortical areas and cerebellum in the AON circuit in each single-subject? * Can we obtain similar results in a small group of patients with Cerebral Palsy (CP), in order to demonstrate the feasibility of this approach for the study of the mechanisms of AON reorganization, after early brain damage? * Are different patterns of functional activation correlated to different clinical characteristics of CP patients? Participants will perform a 7 Tesla MRI scan, with a functional and anatomical dedicated protocol and will have a comprehensive clinical assessment before the MRI exam.


Eligibility

Min Age: 11 YearsMax Age: 40 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying 7T MR exam and clinical assessment for people with brain function and cerebral palsy. The study is currently recruiting participants at 2 locations.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHER7T MR exam

a 7 Tesla MRI scan, with a functional and anatomical dedicated protocol

OTHERclinical assessment

A comprehensive clinical assessment before the MRI exam.


Locations(2)

Fondazione IMAGO7

Calambrone, PISA, Italy

IRCCS Fondazione Stella Maris

Calambrone, Pisa, Italy

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NCT06826287


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