RecruitingNot ApplicableNCT06826924

7-Days Water-Only Fasting or Ketone Supplementation Trial in Prostate Cancer

A Study of 7-days Water-only Fasting or Ketone Supplementation in Patients With Prostate Cancer

Sponsor

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Enrollment

40 participants

Start Date

Jun 3, 2025

Study Type

INTERVENTIONAL

Conditions

Prostate Cancer Prostate Cancer Metastatic

Summary

Activating the immune system to kill cancer cells is a promising therapeutic strategy for some patients with cancer. Unfortunately, current immune-targeting treatments do not work for patients with prostate cancer. In animal models of cancer, fasting can reprogram the body's metabolism and immune cell function to help immune cells kill cancer cells likely by increasing ketosis. The purpose of this study is to determine whether 7 days of water-only fasting or a ketogenic very low-calorie diet or ketone supplementation is safe and feasible for patients with prostate cancer. This will help the investigators develop future studies to test whether incorporating periods of fasting or very low calorie diets or a ketone supplement into treatment plans for prostate cancer can improve outcomes from this disease.

Eligibility

Sex: MALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating whether a 7-day water-only fast (consuming nothing but water for one week under medical supervision) is safe and has any effects on prostate cancer biology — such as slowing cancer growth or changing tumor markers. **You may be eligible if...** - You are a man with early-stage or low-risk prostate cancer - You are on active surveillance (monitoring without immediate treatment) - You are in good general health and have a normal BMI or are only mildly overweight - You are motivated to complete a medically supervised fast **You may NOT be eligible if...** - You have diabetes or blood sugar regulation problems - You have a history of eating disorders - You have cardiovascular disease or serious heart conditions - You are currently on medications that require food intake - You have had recent surgery or serious illness Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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