By Assessing the Continuous Respiratory Physiological Changes Through Prone Position, Determine the Optimal Duration for Prone Position
National Taiwan University Hospital
100 participants
Sep 20, 2024
OBSERVATIONAL
Conditions
Summary
The prone position leads to a more homogeneous distribution of ventilation by inflation of collapsed alveoli and reduction in alveolar hyperinflation. By employing EIT, the study can obtain a thorough comprehension of the ongoing alterations in regional ventilation before and after adopting the prone position. It is also anticipated that there is an impact on inflammation biomarkers before and after the prone position. This assessment aids in determining the ideal duration for prone position therapy, encompassing the necessary hours and days in the prone position.
Eligibility
Inclusion Criteria3
- Acute respiratory distress syndrome
- Age \> 18
- Serial arterial blood gas data：PaO2/FiO2 \<150. The mechanical ventilator setting：FiO2\>0.6, PEEP\>5 cmH2O
Exclusion Criteria8
- Implantable electronic devices (e.g., pacemakers)
- Body mass index \> 30
- Major thoracic and abdominal surgery
- Patients with unstable spine and pelvis conditions
- Pregnant women in the second and third trimesters
- Patients with head trauma, elevated intracranial pressure, or elevated intraocular pressure
- Hemodynamically unstable patients unsuitable for prone ventilation therapy
- Patients with active seizures
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
It utilizes electrical impedance tomography to analyze a series of physiological changes in the lungs following treatment
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06827184