The Efficacy of Modified Olfactory Training Method for Patients With Post-viral Olfactory Dysfunction
A Randomized Trail Protocol to Access Efficacy of Modified Olfactory Training Method for Patients With Post-viral Olfactory Dysfunction
Peking University Third Hospital
150 participants
Mar 22, 2025
INTERVENTIONAL
Conditions
Summary
The goal of this clinical trial is to validate the effectiveness of the modified olfactory training device, the main questions it aims to answer are: Is the modified olfactory training device effective in treating patients with post-viral olfactory dysfunction? Compared to the conventional device, how efficient is the modified olfactory training device for improving olfactory function?
Eligibility
Inclusion Criteria3
- Age 18-80 years old, gender not limited.
- Patients diagnosed with olfactory dysfunction following infections of the upper respiratory tract, as determined by Sniffin' Sticks test (including TDI value test).
- Voluntarily signs the informed consent form.
Exclusion Criteria11
- Patients with post-traumatic olfactory dysfunction, rhinosinusitis-related dysfunction and olfactory dysfunction caused by other reasons.
- Patients with concomitant sinonasal disease.
- Patients with chronic diseases, such as hypertension, diabetes, bronchopneumonia, chronic obstructive pulmonary disease, etc.
- Patients with serious coexisting diseases: such as malignant tumors, etc., with a life expectancy of less than 2 years.
- Patients who cannot tolerate olfactory function testing and treatment.
- Patients who have taken oral glucocorticoids, antibacterial drugs, anti-leukotrienes, antihistamines, or received olfactory training within four weeks will be excluded.
- Patients who are receiving treatment that affects olfactory recovery.
- Patients with smoking habits.
- Patients who are already or plan to be pregnant.
- According to the judgment of the researchers, the patient cannot complete this study or cannot comply with the requirements of this study (such as memory or behavior abnormalities, depression, heavy drinking, previous breach of contract).
- Patients who did not consent for participating in the study.
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Interventions
Conventional olfactory training was designed by Hummel et al. They performed OT using four odors (phenyl ethyl alcohol, rose; eucalyptol, eucalyptus; citronella, lemon; and eugenol, cloves), which are representative of four odor categories on the odor prism proposed by Henning.
Participants will use a modified olfactory training device based on expiratory pressure. Its bidirectional airflow and unidirectional pressure characteristics significantly increased the deposition rate of olfactory odors in the olfactory cleft area, making the patient feel stronger in the nasal cavity during olfactory training.
Based on the traditional olfactory training device, four olfactory odors are replaced by placebo。
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06829706