RecruitingNCT06874426

The Impact of Endoscopic Endonasal Skull Base Surgery on Olfaction

Sponsor

Universitaire Ziekenhuizen KU Leuven

Enrollment

154 participants

Start Date

Mar 18, 2025

Study Type

OBSERVATIONAL

Conditions

Meningioma Pituitary Adenoma Craniopharyngioma Pituitary Disease Endoscopic Pituitary Surgery Olfactory Dysfunction

Summary

In this study, the research team will investigate the incidence and etiology of olfactory dysfunction following endoscopic endonasal skull base surgery, by combining clinical assessments with histomolecular analysis.

Eligibility

Min Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study is measuring how endoscopic skull base surgery — a minimally invasive procedure performed through the nose — affects patients' sense of smell before and after the operation. **You may be eligible if...** - You are an adult patient scheduled to undergo endoscopic endonasal skull base surgery (surgery through the nose to reach structures at the base of the skull) - You have a normal sense of smell before the surgery **You may NOT be eligible if...** - You already have no sense of smell (anosmia) before surgery - You have previously undergone this same type of surgery Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREEndoscopic endonasal skull base surgery

This intervention will be performed as part of the standard-of-care for patients scheduled for endoscopic endonasal skull base surgery for lesions in the (para)sellar region