RecruitingNCT06874426

The Impact of Endoscopic Endonasal Skull Base Surgery on Olfaction


Sponsor

Universitaire Ziekenhuizen KU Leuven

Enrollment

154 participants

Start Date

Mar 18, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

In this study, the research team will investigate the incidence and etiology of olfactory dysfunction following endoscopic endonasal skull base surgery, by combining clinical assessments with histomolecular analysis.


Eligibility

Min Age: 18 YearsMax Age: 70 Years

Inclusion Criteria1

  • Adult patients scheduled for endoscopic endonasal skull base surgery

Exclusion Criteria2

  • Pre-existing anosmia
  • Patients has a history of previous endoscopic endonasal skull base surgery

Interventions

PROCEDUREEndoscopic endonasal skull base surgery

This intervention will be performed as part of the standard-of-care for patients scheduled for endoscopic endonasal skull base surgery for lesions in the (para)sellar region


Locations(3)

KU Leuven

Leuven, Vlaams-Brabant, Belgium

Max Planck Research Unit for Neurogenetics

Frankfurt am Main, Hesse, Germany

Leiden University Medical Center

Leiden, South Holland, Netherlands

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NCT06874426


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