Intra-ureteric Aminophylline Instillation on Flexible Ureteroscopy Procedure
Efficacy of Intra-ureteric Aminophylline Instillation on Flexible Ureteroscopy Procedure: A Randomized Controlled Study
Ain Shams University
129 participants
Mar 1, 2025
INTERVENTIONAL
Conditions
Summary
in this study we are going to evaluate the efficacy of intra-ureteric aminophylline instillation in facilitating ureteric access sheath placement prior to flexible ureteroscopy in reducing ureteric injury rates.
Eligibility
Inclusion Criteria1
- Upper ureteric stones or renal stones \< 2 cm
Exclusion Criteria7
- Ureteric strictures.
- anatomic renal disorders
- functional renal disorders
- Urinary tract infection.
- Coagulopathy and uncorrected bleeding disorders.
- Prior DJ stenting
- any contraindication for aminophylline use: (hypersensitivity to theophylline, ethylenediamine, or any component of the drug formulation, pregnancy or lactation, active peptic ulcer, presence of cardiologic diseases, presence of neurologic diseases, presence of renal impairment and presence of hepatic dysfunction)
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Interventions
Intraureteric aminophylline installation prior to ureteric dilatation
traditional ureteral dilators will be used. We will start by ureteral dilator 6 fr and gradually increase the size up to 12 Fr
Aminophylline will be instilled as in group (A) then followed by traditional ureteral dilatation as in group (B) prior to placing the ureteric access sheath
Locations(1)
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NCT06830577