Transcranial Magnetic Stimulation for Methamphetamine Use Disorder in PLWH
TMS (Transcranial Magnetic Stimulation) for Methamphetamine Use Disorder in People Living With HIV
Gopalkumar Rakesh
30 participants
Mar 11, 2025
INTERVENTIONAL
Conditions
Summary
The purpose of this study is to learn more about how accelerated theta burst stimulation affects methamphetamine craving and brain activity. Theta burst stimulation is a unique transcranial magnetic stimulation (TMS) paradigm that is efficient and potent.
Eligibility
Inclusion Criteria7
- Adults in the age group 18-65 years
- Able to read and understand English
- Able to provide informed consent
- Diagnosed with HIV
- History of current or previous Methamphetamine Use Disorder
- Endorse craving for methamphetamine
- Demonstrate an attentional bias for methamphetamine
Exclusion Criteria9
- Traumatic brain injury
- h/o seizure disorder
- h/o or current diagnosis of schizophrenia
- intracranial metal shrapnel
- previous adverse effects with TMS
- sub-threshold consistency while performing behavioral tasks
- lack of attentional bias to methamphetamine cues
- a positive pregnancy test for female participants
- abnormal brain MRI
Interventions
iTBS is an excitatory TMS paradigm that delivers 1800 pulses to the left dlPFC. Participants will receive 2 iTBS sessions separated by 50 minutes.
cTBS is an inhibitory TMS paradigm that delivers 1800 pulses to the frontal pole. Participants will receive 2 iTBS sessions separated by 50 minutes.
Sham TMS delivered with the MagVenture B65 A/P coil
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06830980