RecruitingNot ApplicableNCT06830980

Transcranial Magnetic Stimulation for Methamphetamine Use Disorder in PLWH

TMS (Transcranial Magnetic Stimulation) for Methamphetamine Use Disorder in People Living With HIV


Sponsor

Gopalkumar Rakesh

Enrollment

30 participants

Start Date

Mar 11, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to learn more about how accelerated theta burst stimulation affects methamphetamine craving and brain activity. Theta burst stimulation is a unique transcranial magnetic stimulation (TMS) paradigm that is efficient and potent.


Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether transcranial magnetic stimulation (TMS) — a non-invasive brain stimulation technique — can help reduce methamphetamine cravings and use in people living with HIV who also have a methamphetamine use disorder. TMS uses magnetic pulses applied to the scalp to influence brain activity. **You may be eligible if...** - You are between 18 and 65 years old - You can read and understand English - You are living with HIV - You have a current or past diagnosis of methamphetamine use disorder and still experience cravings - You show a measurable attention pull toward methamphetamine-related cues (assessed during screening) **You may NOT be eligible if...** - You have had a traumatic brain injury or a seizure disorder - You have been diagnosed with schizophrenia - You have metal fragments in your skull - You have previously had a bad reaction to TMS - You are pregnant - You have an abnormal brain MRI Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEintermittent theta burst stimulation (iTBS)

iTBS is an excitatory TMS paradigm that delivers 1800 pulses to the left dlPFC. Participants will receive 2 iTBS sessions separated by 50 minutes.

DEVICEcontinuous theta burst stimulation (cTBS)

cTBS is an inhibitory TMS paradigm that delivers 1800 pulses to the frontal pole. Participants will receive 2 iTBS sessions separated by 50 minutes.

DEVICESham TMS

Sham TMS delivered with the MagVenture B65 A/P coil


Locations(1)

UK Department of Psychiatry

Lexington, Kentucky, United States

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NCT06830980


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