Impact of PEG Bowel Preparation on Gut Microbiome Composition Recovery
Centre hospitalier de l'Université de Montréal (CHUM)
20 participants
Dec 5, 2024
INTERVENTIONAL
Conditions
Summary
The main objective is to evaluate the impact of intestinal preparation on the composition, diversity and metabolome of the intestinal microbiota.
Eligibility
Inclusion Criteria3
- Healthy volunteer participant cohort:
- > 18 years of age
- The participant has provided documented informed consent for the participation and to complete PEG bowel preparation and return collected stool samples.
Exclusion Criteria10
- An ileus
- Significant gastric retention
- Suspected or established mechanical bowel obstruction
- Inflammatory or infectious gastrointestinal condition
- Neurologic or cognitive impairment that prevents safe swallowing
- Recent history (<1 year) of cancer that still requires ongoing treatment
- Recent use of antibiotics 1 month prior to participation in the trial
- History of cardiac disease
- History of active renal dysfunction
- Presence of any absolute contraindication to PEG bowel preparation according to manufacturer labeling
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Interventions
Volunteers will be administered 4L of PEG bowel preparation. The following instructions will be provided with the prescription: 1. Fill the supplied container containing the bowel cleanse powder with lukewarm water (to facilitate dissolution) to the 4-liter fill line. The solution is clear and colourless when reconstituted to a final volume of 4 liters. 2. After capping the container, shake vigorously several times to ensure that the ingredients are dissolved. The solution is more palatable if chilled prior to drinking. When reconstituted use within 48 hours. 3. Attempt to drink a maximum of 4 liters at a rate of 240 mL (8 oz.) every 10 minutes, until 4 liters has been consumed or the rectal effluent is clear. Rapid drinking of each portion is preferred to drinking small amounts continuously. 4. The first bowel movements should occur approximately one hour after the start of bowel cleanse administration. Continue drinking until the watery stool is clear and free of solid matter.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06831539