An Efficacy, Safety, and Tolerability Study of VX-880 in Participants With Type 1 Diabetes With a Kidney Transplant

This study is testing VX-880 — an experimental cell therapy using transplanted insulin-producing islet cells — in people who have both Type 1 diabetes and a kidney transplant. The goal is to see if this therapy can restore the body's ability to produce insulin naturally and improve blood sugar control. **You may be eligible if...** - You have had Type 1 diabetes for at least 5 years and are dependent on insulin - You have already had a kidney transplant - You have been on a stable immunosuppression regimen for at least 4 weeks - You have been using a continuous glucose monitor (CGM) for at least 4 weeks **You may NOT be eligible if...** - You have had a previous islet cell transplant or any organ transplant other than a kidney - You have had more than one kidney transplant - You have had a pancreatic graft that functioned for more than 4 weeks Talk to your doctor to see if this trial is right for you.