RecruitingPhase 4NCT06834165

Study Evaluating the Safety and Efficacy of Neffy or Intramuscular Adrenalin in Patients With Allergic Reactions After Oral Food Challenge or Allergen Immunotherapy

A Phase IV Study Evaluating the Safety and Efficacy of Neffy or Intramuscular Adrenalin in Patients With Allergic Reactions After Oral Food Challenge or Allergen Immunotherapy


Sponsor

ARS Pharmaceuticals, Inc.

Enrollment

600 participants

Start Date

May 20, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The study is to assess the safety of neffy or IM Adrenalin in patients who are experiencing allergic reactions after an OFC, allergen Immunotherapy (AIT), or other allergy challenge that may require epinephrine intervention.


Eligibility

Min Age: 4 Years

Inclusion Criteria4

  • Is a patient 4 years old or greater, inclusive, who are scheduled to undergo OFC, AIT, or other relevant allergy challenge.
  • Has body weight 15 kg or greater at the time of allergy challenge.
  • Is willing and able to provide written informed consent prior to participating in the study. In the case of minors (<18 years old), assent can be obtained from his/her legal representative, and as much possible from the patient himself/herself.
  • Patient experiences an allergic reaction that, in the opinion of the Investigator, requires treatment with epinephrine via neffy or IM Adrenalin.

Exclusion Criteria1

  • \- Has any clinically significant medical condition that precludes treatment with epinephrine as assessed by the Investigator.

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Interventions

DRUGNeffy

Epinephrine nasal spray

DRUGAdrenaline

Epinephrine injection


Locations(2)

Orso Health, Inc.

La Jolla, California, United States

Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, United States

View Full Details on ClinicalTrials.gov

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NCT06834165