RecruitingPhase 4NCT06834230

Effect of Dotinurad in Hyperuricemia With Hypertension

Effect of Dotinurad in Hyperuricemia With Hypertension: a Randomized Study With Febuxostat (DIANA-NEXT)


Sponsor

Saga University

Enrollment

360 participants

Start Date

Mar 28, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The effect of dotinurad on CAVI (cardio-ankle vascular index) will be compared with that of febuxostat in patients with hyperuricemia complicated by hypertension.


Eligibility

Min Age: 20 Years

Plain Language Summary

Simplified for easier understanding

This study examines whether dotinurad — a newer medication that lowers uric acid by helping the kidneys excrete it — also helps control blood pressure in people who have both gout or high uric acid levels and hypertension. **You may be eligible if...** - You are 20 or older - You have high uric acid levels (above 7.0 mg/dL) and have not taken uric-acid-lowering medication in the past 27 days (or have been off them for at least 27 days) - You have high blood pressure, and your blood pressure treatment plan has not changed in the past 4 weeks - You are willing to give written consent **You may NOT be eligible if...** - Your blood pressure is not well controlled - You have serious kidney, liver, or heart conditions - You are pregnant or breastfeeding - You are taking medications that interact with dotinurad Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGDotinurad

Start at 0.5 mg once daily, and then referring to the attached document, gradually increase the dose to the maintenance dose (2 mg once daily).

DRUGFebuxostat

Start at 10 mg once daily, and then referring to the attached document, gradually increase the dose to the maintenance dose (40 mg once daily).


Locations(1)

Saga University

Saga, Saga-ken, Japan

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NCT06834230


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