RecruitingNot ApplicableNCT06835023

Dextran 40 Plus Ringer's Lactate Vs. Ringer's Lactate Alone for Fluid Resuscitation in Acute Pancreatitis

A Randomized Controlled Trial Evaluating Fluid Resuscitation in Acute Pancreatitis: Dextran 40 and Ringer's Lactate (1:3 Ratio) Versus Ringer's Lactate Alone


Sponsor

Satu Mare County Emergency Hospital

Enrollment

100 participants

Start Date

Jan 10, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

This clinical trial aims to learn if a combination of Dextran 40 and Ringer's lactate solution can improve fluid resuscitation in mild and moderate acute pancreatitis (AP) and prevent complications. The main questions it aims to answer are: Does early fluid resuscitation with Dextran 40 plus Ringer's lactate improve patient outcomes compared to Ringer's alone? Does this treatment reduce inflammation, organ failure, and the need for intensive care unit (ICU) admission? Researchers will compare Dextran 40 plus Ringer's lactate to Ringer's alone to see if the combination therapy is more effective in reducing disease severity and complications. Participants will: Receive either Dextran 40 plus Ringer's lactate (1:3 ratio) or Ringer's lactate alone. Have blood tests every 24 hours to measure inflammation and organ function. Be monitored for changes in disease severity, need for ICU admission, and hospitalization duration. This study will help determine the best fluid resuscitation strategy for treating mild and moderate acute pancreatitis.


Eligibility

Min Age: 18 Years

Inclusion Criteria2

  • adults (≥18 years) diagnosed with mild or moderate acute pancreatitis
  • must provide written informed consent for study participation.

Exclusion Criteria6

  • patients who decline to provide informed consent.
  • patients are non-compliant with treatment and follow-up visits.
  • pregnant individuals.
  • patients requiring concomitant treatment that is contraindicated within the study protocol.
  • patients who develop conditions that contraindicate the administration of the investigational medication.
  • patients experiencing severe adverse reactions necessitating treatment discontinuation.

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Interventions

DRUGRinger lactate (RLS)

50 patients will receive only Ringer Lactat

DRUGDextran+Ringer Lactat(D+RLS)

50 patients Dextran+RInger Lactat 1:3 ratio


Locations(1)

Spitalul Judetean de Urgenta Satu Mare

Satu Mare, Satu Mare County, Romania

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NCT06835023


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