RecruitingNot ApplicableNCT06835595

TMS-related Measures as Biomarker of Cognitive Impairment in PD

Transcranial Magnetic Stimulation (TMS) Related Measures as Biomarker of Cognitive Impairment in Parkinson's Disease (PD)

Sponsor

Azienda Sanitaria Universitaria Integrata del Trentino

Enrollment

52 participants

Start Date

Sep 10, 2025

Study Type

INTERVENTIONAL

Conditions

Parkinson Disease

Summary

The goal of the present study is to explore the diagnostic and prognostic value of neurophysiological biomarkers obtained through paired-pulse Transcranial Magnetic Stimulation (TMS) techniques in individuals affected by Parkinson's disease (PD) with and without cognitive decline. The main questions it aims to answer are: * TMS measures of cortical excitability are able to distinguish between PD patients cognitively normal, PD-Mild Cognitive Impairment (PD-MCI) and PD-Dementia (PD-D)? * TMS measures of cortical excitability are able to predict progression of PD patient cognitive status from cognitively normal to PD-MCI and PD-D?

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study investigates whether a specific type of brain stimulation test called transcranial magnetic stimulation (TMS) — which uses a magnetic pulse to briefly activate brain cells — can act as a reliable marker to detect and track cognitive decline in people with Parkinson's disease. **You may be eligible if...** - You are over 18 years old - You have been diagnosed with idiopathic (typical) Parkinson's disease - Your Parkinson's medications have been stable for at least 4 weeks - You are able to complete detailed thinking and memory tests - You are able to give informed consent **You may NOT be eligible if...** - You have a serious cardiovascular or cerebrovascular condition - You have another active neurological disease in addition to Parkinson's - You have a cochlear implant, pacemaker, deep brain stimulation device, or any other implanted stimulator or metallic device near the brain Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.