Biomarkers for Cognitive Decline in Intracerebral Hemorrhage
Silent Brain Infarcts in Spontaneous Intracerebral Hemorrhage as a Prognostic Biomarker for Vascular Contributions to Cognitive Impairment and Dementia (VCID)
Rush University Medical Center
118 participants
Aug 2, 2025
OBSERVATIONAL
Conditions
Summary
The goal of this clinical trial is to see if silent brain infarcts (SBIs), or stroke-like symptoms detectable during brain imaging, are a possible contributor to cognitive decline for patients diagnosed with spontaneous intracerebral hemorrhage (sICH), or blood clot in the brain. The main questions it aims to answer are * if SBIs in sICH are associated with a lower cognitive level and more rapid cognitive decline * if SBIs in sICH are associated with certain findings on brain imaging * if SBIs in sICH are associated with higher inflammation measured by certain blood tests Participants will undergo * cognitive testing during hospitalization, and at 3, 6 and 12 months after the sICH * Magnetic Resonance Imaging (MRI) of the brain during hospitalization and 12 months after the sICH * blood draws during hospitalization and at 3, 6 and 12 months after the sICH
Eligibility
Inclusion Criteria2
- Primary Intracerebral Hemorrhage
- Age ≥ 18 and < 80 years
Exclusion Criteria4
- ICH score > 2
- Pre-existing dementia
- Prior history of stroke
- Neurosurgical evacuation of hematoma
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Interventions
MRI during hospitalization and at 12 months post sICH
Will occur during hospitalization and at 3, 6 and 12 months post sICH
Cognitive testing will occur during hospitalization and at 3, 6 and 12 months post sICH
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06836141