RecruitingNCT06836141

Biomarkers for Cognitive Decline in Intracerebral Hemorrhage

Silent Brain Infarcts in Spontaneous Intracerebral Hemorrhage as a Prognostic Biomarker for Vascular Contributions to Cognitive Impairment and Dementia (VCID)


Sponsor

Rush University Medical Center

Enrollment

118 participants

Start Date

Aug 2, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

The goal of this clinical trial is to see if silent brain infarcts (SBIs), or stroke-like symptoms detectable during brain imaging, are a possible contributor to cognitive decline for patients diagnosed with spontaneous intracerebral hemorrhage (sICH), or blood clot in the brain. The main questions it aims to answer are * if SBIs in sICH are associated with a lower cognitive level and more rapid cognitive decline * if SBIs in sICH are associated with certain findings on brain imaging * if SBIs in sICH are associated with higher inflammation measured by certain blood tests Participants will undergo * cognitive testing during hospitalization, and at 3, 6 and 12 months after the sICH * Magnetic Resonance Imaging (MRI) of the brain during hospitalization and 12 months after the sICH * blood draws during hospitalization and at 3, 6 and 12 months after the sICH


Eligibility

Min Age: 18 YearsMax Age: 80 Years

Inclusion Criteria2

  • Primary Intracerebral Hemorrhage
  • Age ≥ 18 and < 80 years

Exclusion Criteria4

  • ICH score > 2
  • Pre-existing dementia
  • Prior history of stroke
  • Neurosurgical evacuation of hematoma

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Interventions

DIAGNOSTIC_TESTMRI

MRI during hospitalization and at 12 months post sICH

DIAGNOSTIC_TESTBlood Draw

Will occur during hospitalization and at 3, 6 and 12 months post sICH

DIAGNOSTIC_TESTCognitive Test

Cognitive testing will occur during hospitalization and at 3, 6 and 12 months post sICH


Locations(1)

Rush University Medical Center

Chicago, Illinois, United States

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NCT06836141