RecruitingNot ApplicableNCT06836830

PEEP vs. ZEEP in Out-of-Hospital-Cardiac-Arrest

Peri-Arrest Ventilation With Positive End-Expiratory-Pressure vs. Zero End-Expiratory-Pressure in Out-of-Hospital-Cardiac-Arrest

Sponsor

Muehlenkreiskliniken, MKK

Enrollment

600 participants

Start Date

Jun 1, 2025

Study Type

INTERVENTIONAL

Conditions

Cardiac Arrest (CA)Ventilation Therapy PEEP, Occult CPR

Summary

Out-of-hospital cardiac arrest (OHCA) remains a major cause of mortality, with low survival probabilities to hospital discharge. Despite the frequent use of airway management and mechanical ventilation during resuscitation, there is limited evidence regarding the optimal ventilation strategy to improve oxygen delivery and patient outcomes. The present study aims to investigate the effects of positive-end-expiratory-pressure (PEEP) set at 5 mbar compared to zero-end-expiratory-pressure (ZEEP) on the return of spontaneous-circulation (ROSC) in adult patients with OHCA.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a procedure called PEEP 5 mbar and a procedure called ZEEP 0 mbar for people with cpr, cardiac arrest (ca), and other related conditions. The study is currently recruiting participants at 3 locations. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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