PEEP vs. ZEEP in Out-of-Hospital-Cardiac-Arrest
Peri-Arrest Ventilation With Positive End-Expiratory-Pressure vs. Zero End-Expiratory-Pressure in Out-of-Hospital-Cardiac-Arrest
Muehlenkreiskliniken, MKK
600 participants
Jun 1, 2025
INTERVENTIONAL
Conditions
Summary
Out-of-hospital cardiac arrest (OHCA) remains a major cause of mortality, with low survival probabilities to hospital discharge. Despite the frequent use of airway management and mechanical ventilation during resuscitation, there is limited evidence regarding the optimal ventilation strategy to improve oxygen delivery and patient outcomes. The present study aims to investigate the effects of positive-end-expiratory-pressure (PEEP) set at 5 mbar compared to zero-end-expiratory-pressure (ZEEP) on the return of spontaneous-circulation (ROSC) in adult patients with OHCA.
Eligibility
Inclusion Criteria3
- Adults \>= 18 years
- non-traumatic OHCA
- mechanical ventilation via airway device
Exclusion Criteria3
- Patients \< 18 years,
- traumatic cause of OHCA,
- no cardiac arrest, withholding of resuscitation (e.g. Do-Not-Resuscitate orders)
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Interventions
Positiv-End-Expiratory Pressure
Zero-End-Expiratory Pressure
Locations(3)
View Full Details on ClinicalTrials.gov
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NCT06836830