Inhibiting Beta-adrenergic and COX-2 Signaling During the Perioperative Period to Reduce Ovarian Cancer Progression

This study is testing whether taking two common medications — a beta-blocker (propranolol) and a COX-2 inhibitor (like ibuprofen) — around the time of surgery for ovarian cancer can reduce the spread of cancer cells and improve outcomes. Stress hormones released during surgery may help cancer spread, and these drugs may block that effect. **You may be eligible if...** - You are between 20 and 85 years old - You have suspected high-grade ovarian cancer based on scans, blood tests, or biopsy - You are scheduled for primary surgery or interval debulking surgery for ovarian cancer - Your general health score (ASA) is 1–3 or ECOG 0–2 **You may NOT be eligible if...** - You are allergic to beta-blockers or NSAIDs (anti-inflammatory drugs) - You are already regularly taking beta-blockers or COX inhibitors (aspirin is okay) - You have certain heart conditions that make beta-blockers unsafe - You are participating in another interventional clinical trial Talk to your doctor to see if this trial is right for you.