RecruitingNCT06842108

Relationship Between Hemodynamic Changes and Cardiopulmonary Fitness in Type 2 Diabetes Mellitus Patients

Sponsor

Bahria University

Enrollment

162 participants

Start Date

Oct 1, 2024

Study Type

OBSERVATIONAL

Conditions

Diabetes Mellitus Type 2 (T2DM)

Summary

Diabetes mellitus being metabolic disorder, chronic in nature, is characterized by high levels of glucose in our blood, which often lead to organ dysfunction. Approximately 10.5 % of adult (20-79 years) have diabetes according to international Diabetes federation. Cardiorespiratory fitness (CRF) is the capability of our cardiopulmonary system to make oxygen available to our skeletal muscles during physical activities for prolonged time, and is known to be decreased with diabetes. Hemodynamic parameters are correlated with various cardiovascular disorders but little evidence of hemodynamic changes in diabetes patients is present and more studies must be done. This study aims to establish the link between hemodynamic changes and cardiopulmonary fitness in T2DM patients, which could inform clinical practices and interventions to improve management, reduce cardiovascular risks, and enhance the quality of life for these patients.

Eligibility

Min Age: 30 YearsMax Age: 50 Years

Plain Language Summary

Simplified for easier understanding

This study is examining how blood flow and hemodynamic changes (changes in how the heart and blood vessels respond to physical stress) relate to heart and lung function in people who have controlled type 2 diabetes. Understanding how diabetes affects cardiovascular physiology during activity could lead to better monitoring and treatment strategies for this population. **You may be eligible if...** - You are between 30 and 50 years old - You have controlled type 2 diabetes - You are male or female - You have agreed to participate and signed the informed consent form **You may NOT be eligible if...** - You currently exercise regularly - You have cardiovascular disease (such as coronary artery disease or heart failure) - You have had a stroke or have cerebrovascular disease - You have peripheral artery disease (poor circulation in the arms or legs) - You have lung or breathing problems (such as COPD or pulmonary hypertension) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERExercise tolerance test

• The ETT will be performed using Bruce protocol. The Bruce protocol is a standardized treadmill exercise test used in Exercise Tolerance Testing (ETT) to evaluate cardiovascular fitness and diagnose heart conditions. This protocol is divided into seven stages, each stage duration is 3 minutes and date will be recorded at the end of the each stage. The recorded data will include heart Rate, Rate pressure product (∆RPP), HRR1 and Blood Pressure. STEP 1: Patient Preparation STEP 2: Consent and history: STEP 3: Start of ETT: • Graded Exercise STEP 4: Parameters Recorded During ETT: * Heart Rate: Monitoring heart rate response to exercise stress. * Exercise induced changes in heart rate (∆HR) along with change in rate pressure product (∆RPP) due to excercise intensity. STEP 5: Cardiopulmonary Fitness Assessment VO2 Max

Locations(1)

bahria university Health sciences campus karachi

Karachi, Sindh, Pakistan

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NCT06842108

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