The NUTRIOME Study - a Data-driven Precision Nutrition Intervention

Exclusion Criteria25

• History of diagnosed cardiovascular disease (e.g. stroke, heart disease)
• Diagnosed type 1 or type 2 diabetes
• Finger prick glucose test at screening indicating diabetes (fasting >6.9 mmol/L; non-fasting >11.0 mmol/L)
• Antibiotic use in the last 3 months
• Taking medication that can interfere with the planned outcome measures, as judged by the study physician (e.g. peroxisome proliferator-activated receptor-α \[PPAR-α\] or PPAR-γ agonists \[fibrates\], sulfonylureas, biguanides, α-glucosidase inhibitors, thiazolidinediones, repaglinide, nateglinide and insulin, chronic use of NSAIDs). Statins and hypertension medication are allowed if the medication regimen has been stable for the last three months
• Stomach and gastrointestinal conditions (e.g. Morbus Chron, Ulcerative colitis, irritable bowel syndrome, malabsorption, colostomy, bowel resection, gastric bypass surgery etc.)
• History of major gastrointestinal surgery
• Anaemia: Hb concentrations < 8.5 mmol/L for men and < 7.5 mmol/L for women
• Recent blood donation (within 2 months prior to the screening)
• Recent participation in another intervention study (within 2 months prior to the screening)
• Allergy or intolerance to medical skin adhesives
• Chronic or acute inflammatory conditions (e.g., rheumatoid arthritis, psoriatic arthritis)
• Autoimmune disorders
• Thyroid disorders
• Significant renal or liver dysfunction or chronic kidney or liver disease
• Known food allergies/intolerances to intervention foods or food products used in the study
• Following specific dietary regimen that could impact results or not suitable for the study design (e.g. vegetarian, vegan)
• Habitual tobacco consumption (e.g. smoking, use of snus, vaping)
• Alcohol intake ≥ 14 alcoholic beverages/week for women and ≥ 21 alcoholic beverages/week for men
• Current or planned pregnancy or lactating
• Other serious medical conditions that could interfere with participation or study outcomes
• Unable to sufficiently understand written and spoken national language (where the study centre is located) to provide written consent and understand information and instructions from the study personnel.
• Deemed unsuitable for participation in the trial, for any reason, as judged by the research physician or PI.
• Working at the division conducting the trial at any of the three study centres.
• Do not have a mobile phone that is suitable for the use of a research app.