RecruitingNot ApplicableNCT06843005

Serial Coronary CTA-based Plaque Progression Detection for Management of Coronary Heart Disease

Serial Coronary CTA-based Plaque Progression Detection for Management of Coronary Heart Disease: a Randomised Controlled Trial


Sponsor

Zhang longjiang,MD

Enrollment

3,100 participants

Start Date

Feb 28, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The primary objective of this study is to evaluate whether a management strategy based on coronary computed tomography angiography (CCTA) for patients with non-obstructive coronary artery disease can improve the LDL-C target achievement rate compared to a traditional management strategy without follow-up CCTA, thereby reducing the incidence of major adverse cardiovascular and cerebrovascular events over a 3 years period, including all-cause mortality, myocardial infarction, ischemia driven revascularation and stroke.


Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study uses repeat heart CT scans over time to track how plaque builds up in the coronary arteries of people with known mild coronary artery disease, to improve treatment decisions. **You may be eligible if...** - You are between 18 and 80 years old - You have known non-obstructive coronary artery disease (diagnosed at least 2 years ago) - You are willing to have a follow-up heart CT scan **You may NOT be eligible if...** - You have had a heart attack, stent placement, or bypass surgery - You have had a major cardiovascular event - You have already had a follow-up heart CT scan or coronary angiogram since your initial diagnosis - You have severe liver or kidney problems - You have a contraindication to CT scanning (such as contrast dye allergy) - Your original CT images were poor quality Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTCoronary Computed Tomography Angiography

Based on the assessment of plaque progression after follow-up CCTA examination, patients will be given either intensive treatment or routine treatment.

OTHERCurrent clinical guidelines

Patients will be treated according to the 2024 ESC Guidelines for the Management of Chronic Coronary Syndromes.


Locations(1)

Research Institute Of Medical Imaging Jinling Hospital

Nanjing, Jiangsu, China

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NCT06843005


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