Serial Coronary CTA-based Plaque Progression Detection for Management of Coronary Heart Disease
Serial Coronary CTA-based Plaque Progression Detection for Management of Coronary Heart Disease: a Randomised Controlled Trial
Zhang longjiang,MD
3,100 participants
Feb 28, 2025
INTERVENTIONAL
Conditions
Summary
The primary objective of this study is to evaluate whether a management strategy based on coronary computed tomography angiography (CCTA) for patients with non-obstructive coronary artery disease can improve the LDL-C target achievement rate compared to a traditional management strategy without follow-up CCTA, thereby reducing the incidence of major adverse cardiovascular and cerebrovascular events over a 3 years period, including all-cause mortality, myocardial infarction, ischemia driven revascularation and stroke.
Eligibility
Inclusion Criteria3
- Age between 18 and 80 years old;
- Known patients with non-obstructive coronary artery disease (disease duration ≥2 years);
- Patients who agree to undergo follow-up CCTA examinations and cooperate in completing follow-up observations.
Exclusion Criteria6
- Patients who have experienced ACS or PCI/CABG;
- Patients who have experienced adverse cardiovascular and cerebrovascular events;
- Patients who have undergone follow-up CCTA or DSA examinations before enrollment;
- Patients with severe hepatic and renal dysfunction;
- Patients with contraindications to CCTA examinations;
- Patients with poor initial CCTA image quality or data loss.
Interventions
Based on the assessment of plaque progression after follow-up CCTA examination, patients will be given either intensive treatment or routine treatment.
Patients will be treated according to the 2024 ESC Guidelines for the Management of Chronic Coronary Syndromes.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06843005