RecruitingPhase 1NCT06848868

Ambulatory Flexible URS for UTUC Surveillance

Flexible Ureterorenoscopy for Surveillance of Upper Tract Urothelial Carcinoma-A Pilot Study


Sponsor

Chinese University of Hong Kong

Enrollment

10 participants

Start Date

Jul 1, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This is a a prospective single-arm pilot study to investigate the safety and feasibility of flexible ureteroscopy under local anaesthesia. All consecutive patients who have undergone kidney-sparing surgery for managing upper tract urothelial carcinoma will be screened for study eligibility. The primary outcome is the procedural technical success rate. Secondary outcomes include the 30-day complication rate following flexible ureteroscopy, readmission rates, cost analysis, and patient-reported outcomes. Ureterorenoscopy will be conducted in the recruited patients under local anaesthesia in the ambulatory urology centre. Procedural details, technical success rates, adverse events and patient reported outcomes will be documented. The anticipated risks of this intervention are not expected to exceed those associated with the standard of care, that is ureterorenoscopy under anaesthesia. This pilot study aims to recruit a total of 10 subjects to assess the safety and feasibility of flexible ureterorenoscopy in an ambulatory care setting.


Eligibility

Min Age: 18 Years

Inclusion Criteria3

  • Aged 18 years or older
  • Capable of giving informed consent
  • Having undergone an kidney-sparing surgery (endoscopic operation or segmental ureterectomy)

Exclusion Criteria3

  • Allergy to transurethral lidocaine jelly
  • On anticoagulation or anti-platelet medication with contraindications for cessation prior to the procedure
  • Structural abnormalities in the upper urinary tract on the intended side of examination

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Interventions

PROCEDUREAmbulatory flexible ureterorenoscopy

Ambulatory flexible ureterorenoscopy (experimental)


Locations(2)

Prince of Wales Hospital

Hong Kong, Hong Kong

The Chinese University of Hong Kong

Hong Kong, Hong Kong

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NCT06848868


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