Immunotherapy Combined with Hypofractionated Concurrent Chemoradiotherapy Followed by Immunotherapy in LA-NSCLC

This study is testing whether combining immunotherapy (a drug that helps the immune system attack cancer) with a condensed course of radiation and chemotherapy given at the same time, followed by continued immunotherapy, improves outcomes for patients with locally advanced non-small cell lung cancer (NSCLC) that cannot be removed by surgery. **You may be eligible if...** - You are between 18 and 70 years old - You have been confirmed by biopsy or cytology to have inoperable locally advanced NSCLC (stage IIB–IIIC) - Your cancer has not spread to distant organs - Your general health is adequate and you have lost less than 10% of your body weight recently - Your lung, heart, liver, and kidney function are sufficient to tolerate treatment **You may NOT be eligible if...** - Your cancer has spread to distant organs (stage IV) - You have an active autoimmune disease or are on long-term steroids - You have had prior chemotherapy or radiation to the chest - You are pregnant or breastfeeding - You have serious heart or liver disease Talk to your doctor to see if this trial is right for you.