Novel Subtypes and Treatment Strategies of Patients with Unresectable Combined Hepatocellular Cholangiocarcinoma Based on Multimodal Data

This study is using multiple types of data (imaging, pathology, genomics, and treatment history) to better understand and classify combined hepatocellular cholangiocarcinoma (cHCC-CCA) — a rare liver cancer that has features of both hepatocellular carcinoma and bile duct cancer — in order to identify better treatment strategies. **You may be eligible if...** - You are 18 years of age or older - You have been diagnosed with cHCC-CCA confirmed by tissue biopsy or fluid sample - Your cancer is unresectable (cannot be surgically removed) or has spread (metastatic) - You have received prior treatment (local, systemic, or combined) and have at least one measurable area of disease **You may NOT be eligible if...** - You have a different type of liver cancer (e.g., pure hepatocellular carcinoma or pure cholangiocarcinoma) - You have not received any prior treatment - You do not have measurable disease on imaging Talk to your doctor to see if this trial is right for you.