Acoustic Cluster Therapy (ACT) With Chemotherapy for the Treatment of Locally Advanced Pancreatic Cancer

This study is testing whether adding acoustic cluster therapy (ACT) — a technique that uses tiny gas bubbles and ultrasound waves to temporarily open up tumor blood vessels and improve drug delivery — to standard chemotherapy can improve outcomes for patients with locally advanced pancreatic cancer that cannot be surgically removed. **You may be eligible if...** - You have locally advanced pancreatic cancer (LAPC) or borderline resectable pancreatic cancer that is not suitable for primary curative surgery - Imaging and tissue samples are consistent with inoperable pancreatic cancer - Your doctors have determined you are suitable to receive mFOLFIRINOX chemotherapy (a standard combination chemotherapy regimen) **You may NOT be eligible if...** - You have already received any prior anti-cancer treatment for pancreatic cancer (surgery, chemotherapy, radiation, or investigational drugs) - Your cancer is resectable (surgically removable) upfront - Your general health is too poor to tolerate mFOLFIRINOX Talk to your doctor to see if this trial is right for you.