RecruitingNot ApplicableNCT06851130

Assessing the Immediate Increase in Serum Ferritin After Oral Iron Doses: an Experimental Study in Iron-deficient Women

Sponsor

Swiss Federal Institute of Technology

Enrollment

120 participants

Start Date

Feb 25, 2025

Study Type

INTERVENTIONAL

Conditions

Iron Deficiency (Without Anemia)

Summary

Serum ferritin is a key indicator of body iron stores and is widely used in monitoring iron status. However, oral iron doses can acutely elevate SF levels, potentially biasing assessments of iron stores during supplementation. This study aims to investigate the extent and duration of the acute iron-induced effect on serum ferritin following the administration of a daily iron dose for two months.

Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 45 Years

Inclusion Criteria6

Low iron stores (SF levels < 30 µg/L),
no anemia (Hb > 120 g/L)
no inflammation (CRP < 5 mg/L)
to 45 years old.
Body weight <70 kg
Normal body Mass Index (18.5-26.5 kg/m2)

Exclusion Criteria8

Any chronic or acute disease
Consumption of mineral and vitamin supplements since screening and over the study period
Blood transfusion, blood donation or significant blood loss over the past 4 months,
Pregnant or breastfeeding,
Continuous/long-term use of medication during the whole studies (except for contraceptives)
Therapeutic iron infusion over the past 6 months,
Known hypersensitivity or allergy to iron supplements,
Intention to become pregnant over the course of the study

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Interventions

DIETARY_SUPPLEMENTferrous sulfate 80 mg

1 tablet per day

DIETARY_SUPPLEMENTferrous sulfate 160 mg

2 tablets per day

Locations(1)

Laboratory of Nutrition and Metabolic Epigenetics

Zurich, Canton of Zurich, Switzerland

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NCT06851130

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