Pharmacogenetic-Guided Antidepressant Prescribing in Adolescents With Anxiety and Depression

This study tests whether using a genetic test to guide the choice of antidepressant medication leads to better outcomes for teenagers with anxiety and depression, compared to the usual prescribing approach. **You may be eligible if:** - You are between 12 and 17 years old - You have been diagnosed with depression and/or anxiety as your main concern - Your doctor plans to start you on a new antidepressant medication (specifically an SSRI) - You can speak and read English **You may NOT be eligible if:** - You have obsessive-compulsive disorder, psychosis, bipolar disorder, an eating disorder, autism spectrum disorder, fetal alcohol spectrum disorder, or intellectual disability - You have already tried 3 or more antidepressants without success - You recently started or are planning to change brain stimulation therapy - You have a history of liver or bone marrow transplant - You have previously had genetic testing for medication metabolism (CYP2B6, CYP2C19, or CYP2D6) Talk to your doctor to see if this trial is right for you.