Gene Discovery in CHB Patients to Identify Unknown Pathways That Lead to B and NK Cell Deregulation

This research study looks at the genes of people with chronic hepatitis B (a long-term liver infection caused by the hepatitis B virus) to understand why the immune system's B and NK cells don't work properly in fighting the virus. Healthy volunteers are also included for comparison. **You may be eligible if:** - You are 18 years or older - You have chronic hepatitis B infection (treated or untreated) - You are willing to give written consent and are enrolled in the French social security system - Healthy volunteers aged 18–80 who do not have hepatitis B are also eligible **You may NOT be eligible if:** - You have another liver infection (hepatitis C, HIV, or hepatitis D) - You had a serious liver flare-up in the past year - You have other liver conditions (alcoholism, severe obesity, diabetes, or metabolic syndrome) - You have an immune disease or cancer - You are pregnant or breastfeeding - You have a significant disability or are under legal guardianship Talk to your doctor to see if this trial is right for you.