Clinical Trial of TQB2825 Injection Combined With Chemotherapy in Subjects With Diffuse Large B-cell Lymphoma

Exclusion Criteria27

• Subjects who had or currently had other malignant tumors within 5 years prior to the first dose;
• Previous or current involvement or suspected involvement of the central nervous system by lymphoma;
• Failure to recover from adverse reactions to Common Terminology Criteria for Adverse Events version 5.0 (CTCAEv5.0) criteria ≤ grade 1 from previous treatment;
• History of previous anti-tumor treatment:
• previous use of other antibody drugs targeting CD3 and CD20 at the same time;
• received Chimeric Antigen Receptor T-Cell Immunotherapy (CAR-T) therapy, or other immune cell therapy, or autologous hematopoietic stem cell transplantation (auto-HSCT) within 3 months before the first dose;
• previous treatment with R-GemOx or GemOx;
• received chemotherapy, immunotherapy, monoclonal antibody therapy 4 times before the first dose, 2 times received radiotherapy or small molecule targeted drugs, or subjects who are still within 5 half-lives of the drug, the washout period is calculated from the end time of treatment;
• received treatment with Chinese patent medicines with clear anti-tumor indications in the package insert of National Medical Products Administration (NMPA)-approved drugs 2 times before the first dose;
• Subjects who have undergone major surgical treatment, significant traumatic injury, or expected major surgery during the study treatment period within 4 weeks prior to the first use of medication, or have long-term untreated wounds or fractures;
• Subjects who experience any bleeding or bleeding events ≥ Common Terminology Criteria Adverse Event (CTC AE) grade 3 within 4 weeks prior to the first administration;
• Hyperactive/venous thrombotic events within 6 months prior to first dose,Such as cerebrovascular accident (including transient ischemic attack), deep venous thrombosis and pulmonary embolism or any other history of severe thromboembolism;
• Clinically significant uncontrolled pleural effusion, ascites and more than moderate pericardial effusion requiring repeated drainage;
• Decompensated cirrhosis (Child-Pugh class B or C liver function) and active hepatitis;
• Pulmonary disease, including any of the following: 1) with or without current pneumonitis requiring corticosteroid therapy; 2) with or suspected chronic obstructive pulmonary disease (COPD), and forced expiratory volume in 1 second (FEV1) \< 60% (predicted);
• Brain or mental disorders;
• Have major cardiovascular disease;
• Active or uncontrolled infection (≥ CTCAE grade 2 infection), including bacterial, fungal or viral infections including but not limited to active pneumonia, syphilis and tuberculosis.
• Unexplained fever \> 38.5℃ during screening or before the first dose;
• Renal failure requiring hemodialysis or peritoneal dialysis, previous history of nephrotic syndrome;
• History of immunodeficiency, including HIV-positive or other acquired, congenital immunodeficiency diseases;
• Have or have had prior autoimmune disease requiring treatment.
• Prepare to undergo or have previously received organ transplantation, or have a significant host transplant response, or have previously received allogeneic hematopoietic stem cell transplantation; 19、Need to receive systemic immunosuppressive therapy;
• Known or suspected history of hemophagocytic syndrome (HLH);
• Known hypersensitivity to excipient components of the study drug.
• Subjects who participated in other anti-tumor clinical trials within 4 or 5 half-lives before the first dose.
• Any condition that, in the judgment of the investigator, would jeopardize the safety of the subject or prevent the subject from completing the study.