The Role of Coenzyme Q10 in the Prophylaxis of Oxaliplatin Induced Peripheral Neuropathy in Patients With Colorectal Cancer

This study is investigating whether Coenzyme Q10 (a natural antioxidant supplement) can help prevent or reduce nerve damage (peripheral neuropathy) — a common and painful side effect of oxaliplatin chemotherapy — in patients with colorectal cancer. **You may be eligible if...** - You are 18 or older (male or female) - You have been diagnosed with Stage III colorectal cancer (confirmed by biopsy) - You are scheduled to receive FOLFOX-6 chemotherapy (which includes oxaliplatin) - Your blood counts, kidney function, and liver function are adequate - Your general health score (ECOG) is 0–1 **You may NOT be eligible if...** - You have been exposed to other nerve-damaging drugs (like cisplatin, vincristine, or paclitaxel) in the last 6 months - You have cancer that has spread to other organs (metastatic disease) - You currently take antioxidant vitamin supplements (A, C, or E) - You already have nerve damage from diabetes, thyroid disease, autoimmune disease, or other causes - You have diabetes or inflammatory conditions like ulcerative colitis or rheumatoid arthritis Talk to your doctor to see if this trial is right for you.