RecruitingNot ApplicableNCT06857123

Feasibility of Resting Intervals During Exercise Programs for Individuals With Knee Osteoarthritis

Mechanical and Molecular Determinants of Cartilage Response to Exercise

Sponsor

University of Pittsburgh

Enrollment

20 participants

Start Date

Dec 4, 2024

Study Type

INTERVENTIONAL

Conditions

Knee Osteoarthristis

Summary

This pilot randomize trial tests the feasibility of administering two different exercise programs in people with knee osteoarthritis. One group receives the exercise program administered as usual, and the other group received the exercise program with resting intervals.

Eligibility

Min Age: 45 YearsMax Age: 79 Years

Inclusion Criteria7

Age between 45 and 79 yo.
Clinical diagnosis of primary, early to moderate stage knee osteoarthritis.
BMI range \< 35 kg/m2.
Sedentary lifestyle
Knee joint is the most painful joint in the body.
Ability to speak and understand English.
Willingness to comply with all study procedures and be available for the duration of the study.

Exclusion Criteria14

Non-OA disease of the knee.
Advanced knee osteoarthritis
Knee injection in the past 3 months.
Major knee trauma/surgery in the past 5 years or previous knee surgery with hardware limiting cartilage assessment..
Participate in regular exercise or physical activity .
Participation in an intervention study for knee OA.
Currently using a cane, walker or crutches to walk.
History of cardiovascular disease or hypertension not controlled by medication.
Two or more unexplained falls in the past year.
Inflammatory, autoimmune disorders, neurological, systemic, muscular, or connective tissue conditions that affect walking or ability to exercise.
Contraindication to MRI.
Medical condition or characteristic of the participant that could place the individual at increased risk or preclude s/he from complying with study procedures.
Pregnant female.
Acute or terminal illness.

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Interventions

BEHAVIORALExercise with Rest

Participants in this arm exercise 3 times a week for 12 weeks. Exercise program consists of warm-up, strengthening exercises of the lower major extremity muscle groups, and aerobic training using a treadmill. These sessions include two 45 minute rest periods between exercises and take about two and a half hours.

BEHAVIORALExercise without Rest

Participants in this arm exercise 3 times a week for 12 weeks. Exercise program consists of warm-up, strengthening exercises of the lower major extremity muscle groups, and aerobic training using a treadmill. These sessions include minimal resting periods between exercises and take about one hour.