RecruitingPhase 3NCT06862115

The Effect of Discontinuation of Renin Angiotensin System Inhibitors on the Perioperative Myocardial Injury in Adult Patients Undergoing Colorectal Cancer Surgery

The Effect of Discontinuation of Renin Angiotensin System Inhibitors on the Perioperative Myocardial Injury in Adult Patients Undergoing Colorectal Cancer Surgery: a Randomized Controlled Non Inferiority Study.

Sponsor

Kasr El Aini Hospital

Enrollment

156 participants

Start Date

Mar 1, 2025

Study Type

INTERVENTIONAL

Conditions

Perioperative/Postoperative Complications Myocardium; Injury Angiotensin-Converting-Enzyme Inhibitor

Summary

The aim of this study is to estimate the effect of discontinuation of RAS inhibitors on myocardial injury in cancer patients undergoing major abdominal surgeries.

Eligibility

Min Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at whether stopping certain blood pressure medicines (ACE inhibitors or ARBs) before colorectal cancer surgery reduces the risk of heart injury during and after the operation. **You may be eligible if...** - You are 18 or older - You have been on blood pressure medicines called ACE inhibitors or ARBs for more than 3 months - You are scheduled for major abdominal cancer surgery (lasting over 2 hours, with at least 3 days in hospital) **You may NOT be eligible if...** - You refuse to participate - You had a heart attack within the last 3 months - Your doctor believes stopping your blood pressure medicine could be harmful - You need emergency surgery Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGACE-I and/or ARB antihypertensive treatment

When the ACE-I and/or ARB duration of action is ≥24 hours, the drug will be stopped 48 hours prior to surgery. All other ACE-I and/or ARB will be stopped 24 hours before surgery.