RecruitingPhase 3NCT06862115
The Effect of Discontinuation of Renin Angiotensin System Inhibitors on the Perioperative Myocardial Injury in Adult Patients Undergoing Colorectal Cancer Surgery
The Effect of Discontinuation of Renin Angiotensin System Inhibitors on the Perioperative Myocardial Injury in Adult Patients Undergoing Colorectal Cancer Surgery: a Randomized Controlled Non Inferiority Study.
Sponsor
Kasr El Aini Hospital
Enrollment
156 participants
Start Date
Mar 1, 2025
Study Type
INTERVENTIONAL
Conditions
Summary
The aim of this study is to estimate the effect of discontinuation of RAS inhibitors on myocardial injury in cancer patients undergoing major abdominal surgeries.
Eligibility
Min Age: 18 YearsMax Age: 70 Years
Inclusion Criteria5
- Age \> 18 years
- Both sexes
- ASA 2-3
- Chronic hypertensive patients (\> 3 months before surgery) controlled on ACEIs or ARBs or combination therapy containing one of the RAS inhibitors.
- Scheduled for major abdominal cancer surgery (surgery with an expected duration of \> 2 h from the surgical incision and a postoperative hospital stay of least three days).
Exclusion Criteria4
- Patient refusal.
- Recent myocardial infarction (within 3 months).
- Any condition, which in the opinion of the treating clinician, would result in the patient being harmed by the cessation of the ACE-I and/or ARB therapy.
- Emergency surgery
Interventions
DRUGACE-I and/or ARB antihypertensive treatment
When the ACE-I and/or ARB duration of action is ≥24 hours, the drug will be stopped 48 hours prior to surgery. All other ACE-I and/or ARB will be stopped 24 hours before surgery.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06862115