RecruitingNot ApplicableNCT06863129

Proximal FEmur Reconstruction or Internal Fixation fOR Metastases (PERFORM) Trial

Proximal FEmur Reconstruction or Internal Fixation fOR Metastases (PERFORM) Randomized Controlled Trial


Sponsor

Michelle Ghert, MD

Enrollment

334 participants

Start Date

Feb 1, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to find out if removing and replacing part of the hip bone works better than using metal hardware to stabilize the bone in patients whose cancer has spread to the hip. The main questions are: 1. Does removing and replacing part of the bone work better than just stabilizing it with metal hardware? 2. Does removing and replacing the bone help reduce problems like cancer coming back or the metal hardware breaking? Researchers will compare two treatments: using metal rods and plates to stabilize the bone (internal fixation) versus removing part of the bone and possibly replacing the hip joint (resection and reconstruction) to see if the second option causes fewer problems. Participants will: * Be randomly assigned to one of two groups (internal fixation or resection and reconstruction). * Have one of the two surgeries based on which group they're in. * Go to follow-up appointments with the study doctor at 2 weeks, 6 weeks, 4 months, 6 months, 9 months, and 12 months after surgery.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a procedure called Internal Fixation and a procedure called Resection and reconstruction for people with metastatic bone disease. The study is currently recruiting participants at 13 locations.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREInternal Fixation

Internal Fixation

PROCEDUREResection and reconstruction

Resection and reconstruction


Locations(13)

University of Colorado Hospital

Aurora, Colorado, United States

Parkview Packnett Family Cancer Institute

Fort Wayne, Indiana, United States

University of Maryland Medical Center

Baltimore, Maryland, United States

Albany Medical Center

Albany, New York, United States

University of Cincinnati Medical Center

Cincinnati, Ohio, United States

Good Samaritan Regional Medical Center

Corvallis, Oregon, United States

Oregon Health and Science University Hospital

Portland, Oregon, United States

Medical University Graz

Graz, Austria

Hospital de Clínicas de Porto Alegre

Porto Alegre, Rio Grande do Sul, Brazil

Foothills Medical Centre

Calgary, Alberta, Canada

Mount Sinai Hospital

Toronto, Ontario, Canada

Hôpital Maisonneuve-Rosemont

Montreal, Quebec, Canada

McGill University Health Centre

Montreal, Quebec, Canada

View Full Details on ClinicalTrials.gov

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NCT06863129


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