RecruitingNCT06867419

Metabolic Features Effects on FAST Score in MASLD Patients

Metabolic Features Effect on FibroScan-AST (FAST) Score in Egyptian Patients With Metabolic-Associated Steatotic Liver Disease (MASLD)

Sponsor

Tanta University

Enrollment

385 participants

Start Date

Sep 1, 2024

Study Type

OBSERVATIONAL

Conditions

Metabolic Dysfunction-Associated Steatotic Liver Disease

Summary

The goal of this observational cross-sectional study is to evaluate the effect of metabolic features on Fibroscan-AST (FAST) score stratification in metabolic dysfunction-associated steatotic liver disease (MASLD) patients in Egypt. Researchers will identify the metabolic risk factors in patients with MASLD. evaluate the effect of metabolic features on stratifying MASLD patients by predicting higher FAST score. Participants will be subjected to history taking, clinical examination, laboratory investigations, abdominal ultrasonography, and transient elastography (Fibroscan) to measure liver stiffness (LSM) and controlled attenuation parameter (CAP). The Non-alcoholic fatty liver disease (NAFLD) fibrosis score and FAST score will be calculated.

Eligibility

Min Age: 18 Years

Inclusion Criteria1

All patients with MASLD who had steatosis detected by (VCTE-CAP) elastography

Exclusion Criteria5

Patients with a history of significant alcohol consumption more than 30 g/day in men and > 20 g/day in women.
Patients with positive hepatitis B or C virus markers.
Patients with autoimmune hepatitis.
Patients with any other metabolic liver disease.
Patients with hepatic focal lesions.

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Interventions

RADIATIONTransient Elastography

participants will be subjected to anthropometric measurements, laboratory investigations (complete blood count, liver and kidney functions, lipid profile, virology tests, fasting insulin, fasting sugar, 2 hour postprandial sugar, HbA1c, and HOMA-IR), radiological examination (abdominal ultrasound, Fibroscan). the NAFLD fibrosis score, APRI, FIB-4 score, and FAST score will be calculated.