Effects of Exogenous Ketosis on Proteinuria and Renal Function

This study tests whether drinking a ketone supplement can reduce protein leakage in the urine and protect kidney function in people with chronic kidney disease (CKD) or polycystic kidney disease (PKD). **You may be eligible if...** - You have CKD with moderate protein in the urine (ACR between 200–3000 mg/g) and adequate kidney function (eGFR >30), AND you are already on blood pressure medications and SGLT-2 inhibitors; OR - You have polycystic kidney disease (PKD) with adequate kidney function, on similar medications - Women of childbearing age must use reliable contraception **You may NOT be eligible if...** - You are on dialysis or have very low kidney function - You have poorly controlled diabetes or other serious illnesses - You are pregnant or breastfeeding - You are not on the required background medications Talk to your doctor to see if this trial is right for you.