RecruitingNot ApplicableNCT06871176

PET/MR Scan With [68Ga]Ga-PentixaFor (CXCR4) vs Standard of Care (SOC) for Initial Staging and Follow up in Multiple Myeloma (MM)

[68Ga]Ga-PentixaFor (CXCR4) PET/MR for Initial Staging and Follow up in Multiple Myeloma: Prospective Comparison With Standard of Care PET/CT and Evaluation of Therapy Influence


Sponsor

University Health Network, Toronto

Enrollment

30 participants

Start Date

Apr 22, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

Multiple myeloma is a disease mainly located in participants bones. Usually a participants physician arrives at this diagnosis by doing blood tests and ordering standard of care imaging tests (18F-FDG PET/CT and maybe additional MRI) to see how many bones (and/or other organs) are affected. While these two imaging tests are already very good, recent research indicates that even more precise imaging methods could be used to diagnose participants disease more precisely. The purpose of this study is to learn if a combined PET/MR scan with a new radiotracer, \[68Ga\]Ga-PentixaFor, can provide more accurate and precise diagnostic information in patients with Multiple Myeloma, a type of cancer primarily affecting the bones. This study aims to improve the accuracy of diagnosing and monitoring Multiple Myeloma using more advanced imaging techniques.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is comparing a new type of imaging scan (PET/MR using a tracer called [68Ga]Ga-PentixaFor that targets a protein called CXCR4) versus standard imaging to better detect and monitor multiple myeloma — a cancer of plasma cells in the bone marrow — especially in patients whose disease is harder to track with conventional tests. **You may be eligible if...** - You are 18 years old or older - You have a confirmed diagnosis of multiple myeloma — particularly a type that does not produce measurable proteins (nonsecretory or oligosecretory myeloma), or where there is suspicion of disease outside the bone marrow - You have not received extensive prior treatment **You may NOT be eligible if...** - You are pregnant or breastfeeding - You are unable to lie still in a scanner for at least 30 minutes - You have any contraindications for MRI (such as certain metal implants or pacemakers) - You have a known allergy to the imaging tracer used in the study - You have been diagnosed with another blood cancer (such as lymphoma or leukemia) at the same time Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DRUG[68Ga]Ga-PentixaFor

\[68Ga\]Ga-PentixaFor will be administered intravenously using the recommended activity for adults which is up to 150 MBq (4 mCi) fixed dose. There is no weight adaption recommended in the literature.


Locations(1)

University Health Network

Toronto, Ontario, Canada

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT06871176


Related Trials