Karolinska Schizophrenia Project

This study is a long-term research project investigating the biology of first-episode psychosis — the first time someone experiences a break from reality (such as hallucinations or delusions) — and comparing participants to healthy volunteers to better understand what causes schizophrenia and related conditions. **You may be eligible if...** - You have recently been diagnosed with a first psychotic episode (schizophrenia, brief psychosis, schizoaffective disorder, or similar condition) - You have been on antipsychotic medication for less than 4 weeks - You are able to undergo brain scans and other study procedures - OR you are a healthy volunteer with no personal or immediate family history of psychotic illness **You may NOT be eligible if...** - You have a serious neurological illness, brain tumor, epilepsy, or significant brain injury - You are pregnant or breastfeeding - You meet criteria for a substance use disorder (other than nicotine) - You have had significant radiation exposure in the past year - (For healthy volunteers) You have any major psychiatric illness or a first-degree relative with a psychotic disorder Talk to your doctor to see if this trial is right for you.