Effects of Tirzepatide on Alcohol Intake in Patients Diagnosed With Schizophrenia and Alcohol Use Disorder

This study is testing whether tirzepatide — a medication used for weight loss and type 2 diabetes — can also help reduce heavy alcohol use in people who have both schizophrenia and alcohol use disorder. There is growing interest in whether medications that affect appetite and metabolism may also reduce cravings for alcohol. **You may be eligible if...** - You are between 18 and 70 years old - You have been diagnosed with both schizophrenia and alcohol use disorder - You have a high alcohol use score (AUDIT score above 15) - You have had at least 4 heavy drinking days within a 3-week period recently - Your BMI is 23 or higher **You may NOT be eligible if...** - You have an intellectual disability - You are currently in an acute psychotic episode (very severe symptoms) - You are subject to coercive psychiatric measures - You have conditions that make tirzepatide unsafe, such as a personal or family history of certain thyroid cancers or severe gastrointestinal problems Talk to your doctor to see if this trial is right for you.