Lemborexant in Delayed Sleep Phase Syndrome

This 2-year study is testing whether Lemborexant, a medication that works by blocking the brain's wake-promoting signals, can help people with delayed sleep phase syndrome (DSPS) fall asleep earlier at their desired bedtime. DSPS is a circadian rhythm disorder where people naturally fall asleep 2 or more hours later than they wish, causing daytime fatigue and difficulty waking on time. You may be eligible if you are 18 or older, have been diagnosed with DSPS based on established criteria, do not have significant depression, anxiety, or other sleep disorders, and are not a shift worker or taking medications that strongly affect sleep. Participation involves taking a 5 to 10 mg tablet nightly, tracking your sleep with a diary and wrist monitor (actigraphy), and attending follow-up visits over 2 years. This summary was prepared using AI to help patients understand this research.