RecruitingPhase 4NCT06876649

A Master Protocol to Evaluate the Long-Term Safety of (LY3527727) Pirtobrutinib

A Master Protocol to Evaluate the Long-Term Safety of Pirtobrutinib


Sponsor

Eli Lilly and Company

Enrollment

787 participants

Start Date

May 20, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The master protocol study J2N-MC-JZNY provides a framework to enable the evaluation of the long-term safety and efficacy of pirtobrutinib after completion of clinical studies evaluating pirtobrutinib. The clinical studies that will feed into this master protocol are referred to as originator studies. The master protocol will govern individual study-specific appendices (ISAs) that will represent participants from the individual, completed originator studies. These participants will have the opportunity to enter this study and continue to receive treatment or continue follow-up visits. Overall, the master protocol and the individual ISAs, when combined, define the investigations for this study.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This is a long-term safety follow-up study for patients already enrolled in another Lilly-sponsored clinical trial testing pirtobrutinib, a targeted cancer therapy that blocks a protein called BTK which helps some cancers grow and survive. The goal is to collect extended safety data over a longer period than the original study allowed. **You may be eligible if...** - You are currently participating in a qualifying Lilly-sponsored clinical study that is evaluating pirtobrutinib - Your individual study sub-protocol does not exclude you **You may NOT be eligible if...** - You are not already enrolled in a qualifying pirtobrutinib study - You meet specific exclusion criteria defined in your individual study sub-protocol Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DRUGPirtobrutinib

Administered orally.


Locations(38)

Cancer Specialists, LLC

Jacksonville, Florida, United States

Sylvester Comprehensive Cancer Center

Miami, Florida, United States

Florida Cancer Specialists

Sarasota, Florida, United States

The Emory Clinic

Atlanta, Georgia, United States

Northwestern University

Chicago, Illinois, United States

Dana-Farber Cancer Institute

Boston, Massachusetts, United States

Mayo Clinic- Minnesota

Rochester, Minnesota, United States

University Of Nebraska Medical Center

Omaha, Nebraska, United States

Cayuga Cancer Center

Ithaca, New York, United States

Northwell Health

Lake Success, New York, United States

Memorial Sloan-Kettering Cancer Center (MSKCC) - New York

New York, New York, United States

Memorial Sloan-Kettering Cancer Center (MSKCC) - New York

New York, New York, United States

Memorial Sloan-Kettering Cancer Center (MSKCC) - New York

New York, New York, United States

Duke University Medical Center

Durham, North Carolina, United States

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, United States

University of Pennsylvania Hospital

Philadelphia, Pennsylvania, United States

Tennessee Oncology

Nashville, Tennessee, United States

University of Texas MD Anderson Cancer Center

Houston, Texas, United States

Swedish Cancer Institute

Seattle, Washington, United States

Medical College of Wisconsin

Milwaukee, Wisconsin, United States

Flinders Medical Centre

Adelaide, Australia

Peter MacCallum Cancer Centre

Melbourne, Australia

Linear Clinical Research

Victoria, Australia

CHU de Nantes - Hotel Dieu

Nantes, France

IRCCS-AOU di Bologna-Policlinico S.Orsola-Malpighi

Bologna, Italy

Ospedale San Raffaele

Milan, Italy

Nagoya Medical Center

Aichi-Ken, Japan

National Cancer Center Hospital

Cho-ku, Japan

National Hospital Organization Kyushu Cancer Center

Fukuoka, Japan

Tokai University Hospital- Isehara Campus

Isehara, Japan

Tohoku University Hospital

Miyagi-Ken, Japan

Hokkaido University Hospital

Sapporo, Japan

Pratia MCM Krakow

Krakow, Poland

Instytut Hermatologii I Transfuzjologii

Warsaw, Poland

Seoul National University Hospital

Seoul, South Korea

St James's University Hospital

Leeds, United Kingdom

Churchill Hospital

Oxford, United Kingdom

Derriford Hospital

Plymouth, United Kingdom

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT06876649


Related Trials